Identifying novel gene regulatory functions of glucocorticoids

Project start
Institution: Helmholtz Zentrum München
Applicant: Henriette Uhlenhaut
EKFS funding line: Key Project

The glucocorticoid receptor (GR) is an important immunomodulatory drug target and a potent metabolic regulator. GR is a nuclear hormone receptor that regulates genes in response to steroids such as dexamethasone. However, its mechanisms of action are unknown, and patients on glucocorticoid treatment suffer side effects.
By analyzing the protein complexes that bind to GR in metabolic and immune cells, we have identified novel interaction partners of GR. We hope to elucidate molecular mechanisms employed by GR to control metabolic enzymes or inflammatory responses.
Our genomics, proteomics, and genetics experiments will uncover regulatory layers, to enable the development of new therapeutics for metabolic and immune diseases.

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