Sensory neurons are not only responsible for sensory perceptions, but actively contribute to the regulation of  immune and tissue processes through the release of neuropeptides and neurotransmitters. Therefore, they play a significant role in fighting pathogens, allergic processes and influence wound healing and regeneration. This project aims to characterize age-related changes in stimulus recognition and response in sensory neurons, and to decipher if immune cells are an active driver in the progression of this process. The knowledge obtained herein will help us better comprehend the cause of disrupted tissue and immune balance in aging and build the foundation for the development of therapies for healthier aging.