Diagnostic approaches, genomic insights and treatment concepts of patients suffering from sudden cardiac death in absence of a structural heart disease are limited in Germany. In the present project we aim to study the clinical characteristics, genetic background, and the underlying pathomechanisms of this cohort. Using human cardiomyocytes generated from patient specific induced pluripotent stem cells and in vivo models we aim to understand the pathomechanisms of the underlying diseases and the functional background of several gene variants. The findings of the present project may help to identify several drugs in the treatment of patients to reduce the risk of sudden cardiac death.

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