The Contribution of Salivary Extra-Cellular Vesicles to Taste-Cell Transcriptomics and Eating Behavior in Obesity

Project start
Institution: Helmholtz-Institute for Metabolic-, Obesity- and Vascular Research (HI-MAG)
Helmholtz Center Munich at the University of Leipzig and the University Medical Center Leipzig AöR
Applicant: Kerstin Rohde-Zimmermann
EKFS funding line: First and Second Applications


Saliva contributes to dissolve tastants over the tongues surface. Additionally it harbors components such as extracellular vesicles, small particles that derive from virtually all cells of the body. They serve to exchange information between organs by carrying small molecules such as microRNAs. These microRNAs could potentially influence taste cell function. The aim of this project is to evaluate if changes in the type and constitution of salivary vesicles is altered with respect to bodyweight. Consequences of vesicle-derived microRNAs on the function of taste cells will be addressed by using cell culture systems. The lessons learned from this project could help to understand how obesity influences taste cells and how they could be pharmacologically conducted to address food choices.

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