In Europe, more than 1.5 million endoprostheses are implanted annually. From the time of implantation, there is a risk of bacterial colonization and infection occurs in 0.5 - 2 % of initial implantations and 20 - 40 % of revision procedures. The treatment is complex and often further surgeries are necessary.
A novel anti-infective biopolymer implant coating with externally activatable properties is expected to reduce the risk of infection and improve treatment options. Its efficacy has already been demonstrated in laboratory studies. Funding from the EKFS will now allow to statistically validate microbiological, biomechanical and biochemical properties and to evaluate them in vivo. The funding also includes the development of a concept for the intraoperative application of the coating system.
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