Functional tissue engineering of the human vocal fold with superparamagnetic iron oxide nanoparticles - Magnetic Tissue Engineering (MTE)

Institution: Hals-Nasen-Ohren-Klinik, Kopf- und Halschirurgie, Else Kröner-Fresenius-Stiftungsprofessur für Nanomedizin, Sektion für Experimentelle Onkologie und Nanomedizin (SEON)
Applicant: Dr. Marina Pöttler
Funding line:
First and Second Applications
Caption: Schematic representation of Magnetic Tissue Engineering (MTE): A) Superparamagnetic iron oxide nanoparticles (SPION) uptake; (b) magnetic cell hybrids; C) 3D vocal fold cell-construct

A defect of the vocal fold caused by surgery, for example, still can not be adequately treated. By means of nanotechnology, more precisely by Magentic Tissue Engineering (MTE), the individually reconstruction of human vocal cord tissue can achieved.

Post mortem removed human larynxes are used for the extraction of primary vocal fold cells. After the cells take-up superparamagnetic iron oxide nanoparticles (SPIONs), a three-dimensional, multi-layered and functional cell construct can be generated using an external magnetic field.
The aim of this project is the translation of this method into the human system. This will aid to improve the verbal communication and thus the quality of life of patients.

Here you can get further information.