Development of a biosignature for the chronic rhinosinusitis without nasal polyps

Project start
Institution: Department of Otolaryngology, Head and Neck Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg
Applicant: PD Dr. Sarina Müller
EKFS funding line: First and Second Applications
Graphic
Heat map demonstrating cluster analysis of the top 40 up and down regulated proteins in disease relative to control (color bars display the row- standardized signal values with red representing high and green representing low expression)
(© PD Dr. S. Müller, Prof. Dr. B. Bleier FAU/Harvard)

Goal of the project is the development of a non-invasive biosignature for the chronic rhinosinusitis without polyps. The pathophysiology of the disease will be investigated and a model for monitoring disease severity will be developed.

Potential protein biomarkers will be identified using a multiplexed approach and molecular biological validation methods. Due to the non-invasive design a painless and repetitive sampling is possible. A prospective study will be performed and it will be validated if the biosignature can monitor disease severity and therapeutic effects.


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