Project start

Heat map demonstrating cluster analysis of the top 40 up and down regulated proteins in disease relative to control (color bars display the row- standardized signal values with red representing high and green representing low expression)
(© PD Dr. S. Müller, Prof. Dr. B. Bleier FAU/Harvard)
Goal of the project is the development of a non-invasive biosignature for the chronic rhinosinusitis without polyps. The pathophysiology of the disease will be investigated and a model for monitoring disease severity will be developed.
Potential protein biomarkers will be identified using a multiplexed approach and molecular biological validation methods. Due to the non-invasive design a painless and repetitive sampling is possible. A prospective study will be performed and it will be validated if the biosignature can monitor disease severity and therapeutic effects.
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