The role of tubulin-folding cofactor E (TBCE) on vascular homeostasis and inflammation

Project start
Institution: Center for Cardiology, University Medical Center Mainz
Applicant: Dr. Michael Molitor
EKFS funding line: First and Second Applications


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High blood pressure, diabetes, smoking and lipid metabolism disorders are risk factors for the development of cardiovascular diseases (CVD) which result in heart attacks and stroke, the main causes of morbidity and mortality worldwide. Vascular dysfunction represents an early and decisive step in the development of CVD that cannot be adequately addressed with current therapies. As part of the Gutenberg health study by the Mainz University Medical Center, we deciphered variants of the gene for the structural protein tubulin-folding cofactor E (TBCE), which have important effects on cell structure and the function of blood vessels. The aim of the project is to unravel the relationship between TBCE and vascular homeostasis. In a second step, new treatment strategies will be developed that target TBCE-dependent disorders of vascular function and thus contribute to preventing or slowing down the development of CVD.

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