Chest Area

Periphere Lipolyse als therapeutische Zielstruktur während und nach Myokardinfarkt bei Übergewicht und Diabetes

Institution: Institute of Pharmacology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf
Applicant: Katharina Bottermann
Funding line:
First and Second Applications

In the present project, we will investigate the effects of a heart attack in the context of obesity and type 2 diabetes mellitus on white adipose tissue and here especially on the stimulation of adipose tissue breakdown, also known as lipolysis. It is well known that the stress response of a myocardial infarction stimulates lipolysis, and that lipolytic products are harmful to the heart. Whether and how exactly this connection also applies to patients with obesity and diabetes is not known. However, since these diseases are often associated with a heart attack, the investigation of this relationship is of high importance with respect to possible treatment approaches. Therefore, the inhibition of lipolysis will be investigated as possible treatment option after a myocardial infarction.