Chest Area

Gender-specific mechanisms of inflammation and cardiac dysfunction in doxorubicin-induced heart failure and the role of AMPK

Institution: Department of Cardiology – Cardiology 1, University Medical Center Mainz
Applicant: Dr. Paul Stamm
Funding line:
First and Second Applications

In tumor patients, chemotherapy is often the most important or only therapeutic option. The prognosis of patients depends not only on the response, but also on the side effects of this therapy. Cardiotoxicity, i.e. damage to the heart caused by chemotherapy, is an important side effect. The exact mechanisms of this damage are not yet well understood. In the present project, these effects are investigated using an animal model (mice) in order to improve understanding the cardiotoxicity described and consequently to support the development of preventive and therapeutic measures. Ultimately, this should improve the therapy and prognosis of tumor patients.

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