Chest Area

Translational Precision Medicine for Chronic Lung Diseases

Institution: Dept. of Pneumology and Infectiology, Hannover Medical School (MHH)
Applicant: Dr. Jonas C. Schupp
Funding line:
Else Kröner Clinician Scientist Professorships
PD Dr. Jonas Schupp

Within the scope of projects funded by EKFS Dr. Jonas C. Schupp and his team are researching chronic lung diseases, especially interstitial lung diseases, as well as chronic lung transplant graft dysfunction. The aim of his research is to develop precise treatment approaches, i.e. new therapies precisely tailored to patients’ needs. To accomplish this, modern technologies such as single cell RNA sequencing and spatial transcriptomics are used to characterize aberrant cell populations and gene expression patterns at the single cell level in a spatial tissue context. The development and validation of biomarker panels for early detection, prognosis assessment and personalized therapy ensue based on this. He ultimately aims to attain the development and preclinical validation of new cell-type-specific therapeutic approaches.