Our understanding of the pathophysiological mechanisms involved in the development of coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM) has increased considerably in recent years. However, not all risk factors have been identified. Through our analyses of 47 different laboratory parameters (biomarkers) obtained from plasma and serum from a total of 19 metabolic pathways, we expect new insights into the relevance of different mechanisms in the development of T2DM and CHD. In addition, we would like to use the available biomarker data and genetic variants to improve existing prediction models for the identification of individuals with an increased risk of T2DM or CHD.

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