Accumulating evidence has shown that gut-microbiota related metabolites may contribute to the development of cardiovascular diseases. Endothelial lesions and dysfunction are early vascular hallmarks in the development of atherosclerotic heart disease. Within the funded project we aim at evaluating the impact of distinct gut-microbiota related metabolites on regeneration and repair mechanisms of endothelial cells in arterial vessels after injury. The findings of our project may contribute to our understanding about the link between the gut-microbiome and its metabolites and the development of cardiovascular disease. Our long-term goal is to develop novel preventive and therapeutic strategies by targeting the gut-microbiom to treat patients with cardiovascular disease.  

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