The reserve and maturation of oocytes in their follicles (oocyte and surrounding somatic cells) within the ovary is a crucial factor for female fertility. Disturbances in this process (oocyte maturation and folliculogenesis disorders) can manifest themselves as premature ovarian exhaustion (“premature ovarian insufficiency”) or as a “poor response” to hormonal fertility treatment. The aim of our work is to identify molecular genetic connections and to recognize possible genetic causes and influencing factors for disorders of folliculogenesis and ovarian reserve in order to better adapt and improve the prognosis and therapeutic options of women who want to have children in the future.

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