Transplantation medicine – strategies for ex vivo repair of donor livers and kidneys

Institution: Ludwig-Maximilians-University Munich
Applicants: Prof. Dr. Christian Lange (Sprecher), Dr. Dionysios Koliogiannis (Stv. Sprecher), Prof. Dr. Hans-Joachim Anders (Stv. Sprecher)
Funding line:
Else Kröner Research Schools
Dr. Koliogiannis and Prof. Lange before machine perfusion of a donor liver

This research school is devoted to researching new strategies towards the molecular repair of organ transplants. Numerous patients on the waiting list for an organ transplantation die due to the shortage of donor organs. This lack of donor organs is exacerbated because many of the organs donated are unable to be transplanted due to pre-existing defects. The recent development of machine perfusion-based organ conservation, which enables perfusion of explanted organs with blood or optimized perfusion solutions via pump, has opened the possibility to repair donor organs with therapeutic agents ex-vivo. As a result of this, the quality of donor organs could be improved by administering medications into the pumping cycle. The enthusiasm of young Clinician Scientists for this subject matter is going to be aroused in the research school while they are trained using a concept designed for long-term implementation.

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