Abdominal Area, Kidneys & Pelvis

Towards more efficient therapies for immune-mediated kidney diseases through better understanding of B cell and plasma cell development

Institution: Department of Nephrology and Medical Intensive Care, Charite-Universitätsmedizin Berlin
Applicant: PD Dr. Eva Schrezenmeier
Funding line:
Else Kröner Excellence Fellowships

Chronic Kidney Disease (CKD) affects around 10% of the global population and is one of the leading causes of death. Approximately 20% of CKD cases are due to immune-mediated diseases such as Membranous Nephropathy or ANCA-associated Vasculitis. These diseases vary greatly in their course, ranging from mild and self-limiting to severe and inadequately treatable. B and plasma cells play a key role in their pathogenesis. The goal of this project is to investigate the differences in the development and maintenance of B and plasma cell memory across various disease trajectories. These insights aim to enhance the targeted use of existing therapies and develop new treatment methods.