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Situation:

Compared to the conflict-affected East of the country, the South West has received little attention from the international community, and yet the health needs of the population are great. International assistance is largely focused on the prevention and management of infectious diseases, however, the burden of disease requiring surgical intervention-such as trauma, cancer, infection,and complications from childbirth-is substantial and growing. Surgery is an integral component of any properly functioning healthcare system.

In this funding project, we will test a novel therapy option for acute myeloid leukemia (AML) treatment, in which tumor cell-specific antibodies as transport molecules are used to introduce siRNAs as an efficient therapeutic agent into the AML cells, where they are able to silence malignant modified gene products and thus inhibit leukemia growth.

Sepsis is an indication with an enormous unmet medical need. In western countries, more people die from sepsis than from the most common types of cancer combined. There is no effective and causative treatment available yet. To address this unmet medical need, we are developing alphaSEPT. alphaSEPT is a novel human immune signaling molecule developed in the laboratory of Prof. M. Feige. It has immunomodulatory properties that in the case of indications caused by an immune system out of control, are of central therapeutic importance.