Immune System

Identification of immunological characteristics which influence the response to immunotherapies

Institution: I. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf
Applicant: Dr. Jan Kempski
Funding line:
Else Kröner Memorial Fellowships

The interaction between the immune system and cancer cells remains poorly understood. With the advent of new immunotherapies, understanding this relationship between immune and cancer cells is becoming increasingly important. Indeed, immunotherapies can be associated with inflammatory responses that resemble autoimmune diseases and often require discontinuation of treatment. In this project, the team will investigate how immunological signals affect the efficacy of immunotherapies and what factors lead to intestinal inflammation under these therapies. In particular, we will investigate the interaction of intestinal bacteria and immune cells. The aim of the project is to identify factors that can predict the response to immunotherapy and the occurrence of inflammatory side effects.