Immune System

Dissecting the role of bone metastasis-educated neutrophils in inflammation

Institution: Institute of Experimental Pathology, Centre of Molecular Biology of Inflammation (ZMBE), University of Muenster
Applicant: Dr. Claudia Tulotta
Funding line:
First and Second Applications

Neutrophils are the most abundant immune cell type in our blood and first-responders during inflammation and infection. Cancer cells are malignant cells that can move away from the tissue where they are formed, seed and grow in secondary organs. This process is called metastasis and is the leading cause of cancer-associated deaths. Bone metastasis may link to increased risk of infection and inflammation. When cancer cells colonise the bone marrow, site where neutrophils are formed, they alter the maturation of neutrophils. Resulting immature neutrophils may be harmful and unable to respond to inflammation or infection. Defining if immature neutrophils in bone metastasis are damaging is a step ahead in the battle against cancer and inflammation.

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