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Tumors can evade immune surveillance by employing different escape mechanisms. Several immunotherapies can block relevant elements in these escape mechanisms and enable an immune response attacking tumor cells. This therapeutic strategy has proven to be effective in multiple tumor entities, however not in pancreatic cancer. A detailed understanding of the complex immunological  processes in pancreatic cancer is therefore urgently needed. The metabolic requirements of tumor and immune cells have a critical influence on the response to immunotherapy. The research project led by PD Dr.

Situation: 

In Ghana, there are an estimated 2.5 million people in need of prosthetics & orthotics (P&O) care, including more than 846,000 children. However, there is currently a dramatic shortage of qualified specialists to adequately meet this demand for prostheses and orthoses.

Objectives:

Situation:

78% of Putumayo's population is rural and ethnically diverse. 95.5% of homes have unsatisfied basic needs. Hypertension and diabetes are within the 10 leading causes of morbidity in 2021. 19% of minors suffer malnutrition. The incidence of chronic diseases is higher in rural areas, where access to health services is limited. This leads to a worsening of pathologies, increasing the risk of disability and morbidity.

Project Objective: 

Situation: 

Numerous people in Ukraine have had to undergo limb amputation. In addition to the restrictions that an amputation places on daily activities, those affected often suffer from phantom limb pain that is difficult to treat. Under the conditions of war in Ukraine, it is difficult to provide the large number of amputees with access to appropriate pain management care.

Autophagy is an intracellular process to break down defective proteins, pathogens or damaged cell constituents and reuse the respective materials. It takes place in all cells of the body and helps to renew cellular components.  In the event of nutrient deficiency this process also serves for energy production. Autophagy is impaired in many diseases such as cancer, as well as cardiovascular, neurodegenerative, metabolic and other diseases.