Understanding the positive effect of antibiotics to influence chemotherapies in pancreatic cancer

Institution: ll. Medical Department, University Medical Center Hamburg-Eppendorf
Appilcant: Dr. Joseph Tintelnot
Funding line:
First and Second Applications

Chemotherapy is the treatment of choice for patients suffering from pancreatic ductal adenocarcinoma (PDAC), however, only some patients respond to the treatment. In preclinical models of PDAC, mice receiving an antibiotic combination responded better to clinically used chemotherapies. Antibiotics are known to strongly change the composition of bacteria that inhabit our body. Whether antibiotics change the efficacy of chemotherapies by modulating our endogenous bacteria will be the center of this research proposal. Revealing such an interaction might have an important impact to define new therapeutic approaches to improve the response to chemotherapies in PDAC patients.

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