March 2024 $$ Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNA

Paper: Blood
Author: Dr. Jan-Michel Heger
Institution: Klinik I für Innere Medizin, Uniklinik Köln

Project description:

Central nervous system lymphoma (CNSL) is a rare subtype of aggressive B-cell lymphoma that remains challenging to treat. A significant proportion of patients suffer from progressive disease or severe toxicities early on. Current risk stratification strategies include clinical factors and magnetic resonance imaging for response evaluation but are insufficient in reliably predicting a patient’s risk of relapse. Here, the team applied circulating tumor (ct)DNA sequencing to blood samples obtained from 67 patients with CNSL. Integrating clinical with molecular features of the disease, they developed and independently validated a novel tool for risk stratification in CNSL: the Molecular Prognostic Index for CNSL (MOP-C). MOP-C is highly predictive of relapse, will be validated in a prospective clinical trial and might thus allow for improved treatment guidance in patients with CNSL.


Heger JM, Mattlener J, Schneider J, Gödel P, Sieg N, Ullrich F, Lewis R, Bucaciuc-Mracica T, Schwarz RF, Rueß D, Ruge MI, Montesinos-Rongen M, Deckert M, Blau T, Kutsch N, Balke-Want H, Weiss J, Becker K, Reinhardt HC, Hallek M, Borchmann P, von Tresckow B, Borchmann S. Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNA. Blood. 2024 Feb 8;143(6):522-534. 

Here you can find the Paper. 

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