Glioblastoma are incurable brain tumors characterised by their diffuse invasion and colonization of the entire brain. Another hallmark of these intractable cancers is their molecular and cellular heterogeneity.
In this study, novel methodologies were established to overlay the role of previously unknown role of molecular cell states with their biological function. Suprisingly, it could be seen that neuronal-like cell states are associated with invasiveness of tumor cells. Furthermore, the subpopulation of glioblastoma cells showed patterns of invasion that were resembling those of neurons during developments. Lastly, it could be seen that neuronal activity drives glioblastoma cell invasion. Taken together, three neuronal mechanisms of invasion could be uncovered paving the way for novel clinical-translational therapeutic strategies.
Venkataramani, V., Yang, Y., Schubert, M.C., Reyhan, E., Tetzlaff, S.K., Wissmann, N., Botz, M., Soyka, S.J., Beretta, C.A., Pramatarov, R.L., et al. (2022). Glioblastoma hijacks neuronal mechanisms for brain invasion. Cell 185, 2899-2917 e2831.
Submitting the Paper of the Month:
Else Kröner-Fresenius-Stiftung is using the series “Paper of the Month” to report in an exemplary and hot-off-the-press style on the outstanding work being done by the scientists it supports. We regularly present publications which have recently appeared in especially renowned journals, have emerged from foundation funding and been given appropriate acknowledgment. This is done in the respective categories “Original Paper” and “Review”. In the case of each of these publications, the first author and/or senior author are being funded by the foundation.
We invite all project managers, fellowship recipients and members of graduate study programs to send their work in accordance with the stated criteria as proposal for Paper of the Month to Ms. Anne Asschenfeldt (firstname.lastname@example.org).