Brain
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In-vivo dysregulation of cerebral non-OXPHOS metabolism as a mitochondrial endophenotype of patients with Parkinson disease

Institution: Dpt. of Neurology, University Medical Center Schleswig-Holstein, Campus Lübeck
Applicant: Dr. Jannik Prasuhn
Funding line:
First and Second Applications
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Parkinson's disease is a widespread condition that hampers movements and greatly impacts the daily life of patients. In this research, the scientists question how the brain in patients with Parkinson's disease processes glucose - the main fuel for our brains. Using state-of-the-art techniques and specially marked glucose, they can precisely trace how glucose is used in the human brain to generate energy. This knowledge helps to  better understand Parkinson's disease mechanisms and lays the groundwork for developing new treatments. The aim is to make significant strides in Parkinson's disease research and further use the insights gained to develop new and individualized treatment approaches.