Untersuchungen zur Rolle des Epithelialen Zell-Adhäsionsmoleküls (EpCAM) bei der Biogenese von extrazellulären Vesikeln und deren pro-tumorigenem Phänotyp

Project start
Institution: Universitätsklinikum Münster, Medizinische Klinik A
Applicant: Dr. Kerstin Menck
EKFS funding line: First and Second Applications
Image Menck

Each cell in the human body constantly secretes microscopically small particles, the so-called extracellular vesicles. They act as messengers transferring components from the secreting to surrounding cells and can thus influence the latter. Cancer cells, in particular, release such vesicles to create a favourable organ microenvironment that favors tumor growth. In this project the mechanisms leading to vesicle release will be investigated in order to define novel therapeutic approaches that can block this process. EpCAM, a molecule found at high levels on the surface of cancer cells, will play a central role in the analyses as it has been shown to regulate vesicle formation.

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