Neuronal signals across the entorhino-hippocampal projection play a fundamental role in complex brain function, such as spatial memory and learning. Indeed, evidence has been provided that these signals are altered in patients with Alzheimer’s disease, which may explain some of the major symptoms.

However, the properties and mechanisms of synaptic transmission have not yet been assessed at the level of individual neurons at this clinically relevant projection. This project addresses structural and functional synaptic features at the level of individual connected pairs of neurons in entorhino-hippocampal tissue cultures. Our findings are expected to provide new important insights on basic mechanisms of entorhino-hippocampal signal processing in health and disease.

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