Type 1 Diabetes in Ghana and Germany – Immune pathology of early versus late disease onset and influencing genetic and environmental factors

Project start
Institution: Klinik für Allgemeine Pädiatrie, Neonatologie und Kinderkardiologie, Universitätsklinikum Düsseldorf
Applicant: Julia Seyfarth
EKFS funding line: first application

Collaboration with African partners to investigate reasons for different onset age of Type 1 Diabetes in Germany and Ghana

Type 1 Diabetes is a chronic autoimmune disease characterized by irreversible destruction of pancreatic insulin-producing cells. In Caucasians, Type 1 Diabetes onset is frequently diagnosed during childhood, predominantly between 5 and 15 years. In contrast, Type 1 Diabetes in sub-Saharan Africa is characterized by a significantly later age at onset with a delay of approximately 10 years.

This project aims to investigate the role of differential immune pathology, genetics and infections contributing to differences in onset age. Type 1 Diabetes patients in Germany and Ghana will be recruited. Investigation of immune system key factors important for the age of Type 1 Diabetes onset will help to develop therapeutic approaches to prevent or delay the disease.