Cellular senescence describes a complex cellular program which can activated by various stress factors. It is thought that the accumulation of senescent cells promotes the progression of organ scarring. The molecular mechanisms of cellular senescence in kidney and heart scarring are poorly understood. In this project, the role of the transcription factor RelA as a possible initiator of senescence in kidney and heart scarring will be investigated. In addition, the study will reveal potential new therapeutic approaches to eliminate senescent cells. The results will elucidate the role of RelA and senescent cells as potential targets for intervention in kidney and heart scarring.
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