Ten-year longitudinal investigation of DNA methylation in patients with Parkinson’s disease from the DeNoPa cohort

Institution: Institute of Neurogenetics, University of Lübeck
Applicant: Dr. Alexander Balck
Funding line:
First and Second Applications

Parkinson's disease exhibits a variable course and various symptoms. Genetic changes have been identified in approximately 10% of cases, while the causes of the remaining cases remain unclear. In addition to genetic information, DNA methylation also influences information transmission within cells. This methylation is to be investigated in the De Novo Parkinson (DeNoPa) cohort over a period of ten years. The objective is to create and compare methylation profiles to identify differences and analyze changes in the course. DNA regions with methylation alterations will be investigated more closely to discover new genes and regulatory mechanisms. The study results enhance understanding of the progression of Parkinson's disease and could potentially be utilized for personalized patient counseling in the future.

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