Ulcerative colitis (UC) is an incurable chronic intestinal disease which can severely reduce the quality of life for those affected. Even though novel therapy options are available, a long-term remission (absence of symptoms and inflammation) cannot be achieved in a large proportion of UC patients. In this project modern sequencing technologies will be utilized to detect complex molecular signatures displaying spatial resolution (spatial multi-omics) in intestinal biopsy samples from UC patients receiving biological therapy. The aim is to identify molecular predictors for long-term remission. This project will therefore contribute to biomarker-based precision medicine for patients suffering from UC.

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