The role of microglia in the translational 5xFAD wildling mouse model of Alzheimer's disease

Project start
Institution: Institute of Neuropathology, University of Freiburg, University Hospital
Applicant: Daniel Erny
EKFS funding line: Else Kröner Excellence Fellowship

Microglia are important for brain function and play a very important role in Alzheimer's disease (AD). In AD toxic beta-amyloid (Aβ) depositions accumulate in the brain. As a result, nerve cells die in the course of the disease and certain brain functions such as orientation and memory are increasingly impaired. Microglia remove Aβ deposits in order to protect the nerve cells. In previous studies, the applicant found that microglia are significantly influenced by certain bacterial molecules. In this research project, he wants to elucidate how a natural composition of intestinal bacteria affects microglia and AD pathology in the wildling model, in order to enable new therapeutic options.

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