Professorship of immunomodulation through targeted cell trafficking

Project start
Institution: Medicine 1, University Hospital Erlangen
Applicant: PD Dr. Dr. Sebastian Zundler
EKFS funding line: Clinician Scientist Professorship

The trafficking of immune cells between and within different organs plays a key role in the development of chronic inflammation. In particular, this has been established in inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis and has led to new therapies.
In the frame of this Clinician Scientist Professorship, I will investigate innovative precision approaches centering around immune cell trafficking to develop novel therapeutic options and to optimize existing treatments. We especially focus on exploring, how immune cells in the tissue lead to disease flares, how the deformability of cells impacts on their trafficking, how immune cell trafficking contributes to the communication of the gut with other organs and how the efficacy of therapeutic agents interfering with cell trafficking can be predicted in a personalized way.

Here you can find further information.