The present project aims at closing decisive gaps in our pathophysiological understanding of sleep disordered breathing in patients with (precapillary) pulmonary hypertension and in patients with systolic heart failure. In these groups of patients the immediate effects of established nocturnal mask based therapies on not only respiratory (sleep disordered breathing related) parameters but also on cardiac and autonomic nervous system function parameters will also be investigated critically. 

These insights are supposed to make a contribution to the development of new therapeutic options for treatment of sleep disordered breathing and the indications to initiate such treatments in these patient cohorts. In our opinion treatment of sleep disordered breathing in both patients with pulmonary hypertension and patients with systolic heart failure requires not only respiratory parameters but also cardiac and autonomic nervous system function parameters under mask based therapy to be monitored closely.

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