Pancreatic cancer initiation through IPMN precursor lesions modelled in GNAS-mutated human pluripotent stem cell derived ductal organoids

Project start
Institution: Ulm University Hospital, Department of Internal Medicine I
Applicant: Meike Hohwieler
EKFS funding line: First and Second Applications
Imaging of immunofluorescent staining of pancreatic duct-like organoids generated from human induced pluripotent stem cells

Pancreatic cancer is one of the leading causes of cancer-related deaths, which can be partly attributed to the lack of measures for early disease detection and of curative treatment.
Using human pluripotent stem cells that will be equipped with defined oncogenes and differentiated towards pancreatic cells, we plan to mimic the early development of pancreatic cancer in cell culture and in mice. The focus is on a driver mutation in the GNAS gene causing an increased risk of developing pancreatic tumors in patients with McCune-Albright syndrome. Through our analyses, we aim to gain new insights into pancreatic cancer initiation and progression eventually providing novel aspects for development of early diagnostics and revealing targets for personalized therapy.


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