Organotypic slice cultures of pancreatic ductal adenocarcinoma – a preclinical multi-OMICS approach for development of personalized treatment strategies

Institution: Department of Surgery, University Medical Center Schleswig-Holstein, Campus Lübeck
Applicant: PD Dr. Rüdiger Braun
Funding line:
First and Second Applications

Pancreatic cancer is one of the most common causes of cancer-related deaths worldwide. In most patients, the tumor cannot be removed by surgery. Therefore, drug treatment options play a major role. The biology of each individual tumor is very different, so personalized therapies are becoming increasingly important. This project aims to establish a model in which the tumor is cultivated as an intact tissue section and used for individual treatment response testing. Remarkably, the tissue context is completely preserved in this cultivation model and the individual tumor biology is examined in the spatial tissue context. The results of this study might help to transfer this model system to personalized clinical care.

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