Gliomas are the most common brain tumors in children and adolescents, ranging from benign forms to life-threatening tumors despite intensive treatment. Currently, treatment decisions are often based on symptoms and imaging, although genetic alterations in tumor cells can provide valuable insights into tumor biology. This project aims to explore how genetic features of gliomas can be used to better predict disease progression and tailor treatments to the individual tumor. To achieve this, we analyze data from over 1,500 young patients collected through long-term studies and develop molecularly defined risk groups. The goal is to establish new, more precise treatment recommendations that can be directly implemented in clinical trials.

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