Chronic inflammatory processes triggered by metabolic changes, known as “metaflammation", are key factors in the development and progression of various chronic diseases as well as cancer development. Unhealthy lifestyles, environmental factors, chronic infections, and genetic predisposition drive these metabolic changes and lead to disruption of the balance in many organs. However, the precise interactions between chronic inflammation and metabolic changes remain largely unknown. It is also unclear how metaflammation impacts cancer development and response to different cancer therapies, particularly immunotherapy. Due to the increasing incidence of metabolic disorders, there is an urgent need to improve our understanding how metabolic and chronic inflammatory diseases interact and to develop novel targeted treatment approaches. Within the framework of the Else Kröner Medical Scientist Research Group Lübeck, we aim to explore the role of metaflammation as both cause and consequence of chronic inflammatory diseases, leveraging expertise from diverse research areas at the University of Lübeck. 

Here you can find furter information.