Mechanisms of immunotherapy-induced brain tumor-reactive T helper cells

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Institutions: Neurology Clinic, Medical Faculty Mannheim, University Heidelberg
Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center, Heidelberg
Applicant: Lukas Bunse, MD
EKFS funding line: Else Kröner Memorial Fellowship
working in a neuroimmunological wet lab

Immunotherapies (IT) have successfully entered the clinical arena of oncology. From a neuro-oncological perspective, IT has not been a breakthrough, yet, but first clinical trials show immunotherapeutic efficacy. Immunotherapeutic modalities are manifold, including vaccinations of peptides, of ribonucleic acids, and cellular therapies. Essential for all above-mentioned modalities is the selection of a suitable tumor-specific target to be attacked by the immune system. The applicant has shown that IDH1R132H, a frequently altered protein in brain tumors, is recognized by T helper cells and suitable for IT. Here, with the help of single cell immune receptor sequencing, Dr. Bunse aims at understanding intratumoral mechanisms of tumor-reactive T helper cells to improve IT for brain tumor patients.

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