“Key to Complexity” explores, at the molecular and cellular level, how mutations in the SHOC2 gene – part of the RAS/MAPK signaling pathway – alter communication and control within immune cells. By gaining these basic scientific insights, the team aims to uncover how such mutations may dysregulate immunity and initiate lupus. Over the next three years, this foundational knowledge will then be leveraged toward developing earlier diagnostic methods and targeted treatments, ultimately aiming to deliver more effective care with fewer side effects for patients.

Further information here.