Clonal hematopoiesis of indeterminate potential (CHIP) is a significant age-related phenomenon and a risk factor for both hematological and non-hematological diseases. Despite established risk stratification systems, many factors contributing to the development and progression of CHIP remain unclear, which is why the CHIP Clinic TUM and the "Deutsche CHIP Register e.V." were founded. The aim of this project is to gain new insights into clonal dynamics and risk factors through substantial expansion of the CHIP cohort and prospective nationwide data collection in Germany. Utilizing artificial intelligence, personalized monitoring strategies and more precise risk stratifications will be developed. Additionally, CHIP will be characterized within novel immunotherapies such as CAR T-cell therapy. Overall, this project aims to significantly deepen the understanding of CHIP and develop therapeutic strategies to improve outcomes for individuals with CHIP.

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