The influence of retinal microglial cells on the development and regression of pathological retinal neovascularization - mechanisms and therapeutic options

Project start
Institution: Eye Center, Medical Center, Freiburg
Applicant: Prof. Dr. Dr. Clemens Lange
EKFS funding line: First and Second Applications
Group Picture, AG Lange Freiburg

Retinal neovascularization (RNV) are among the principal causes of visual loss worldwide. The biochemical events responsible for RNV are to date not fully understood. Recently microglia (MG), the resident immune cells of the retina, have been discussed to be implicated in the development of RNV. However, the underlying molecular and cellular mechanisms still need to be explored. In this project we aim to characterize the role of microglia cells during RNV formation in different mouse models by applying RNA-sequencing and to determine potential treatment targets for the future.  

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