Retinal neovascularization (RNV) are among the principal causes of visual loss worldwide. The biochemical events responsible for RNV are to date not fully understood. Recently microglia (MG), the resident immune cells of the retina, have been discussed to be implicated in the development of RNV. However, the underlying molecular and cellular mechanisms still need to be explored. In this project we aim to characterize the role of microglia cells during RNV formation in different mouse models by applying RNA-sequencing and to determine potential treatment targets for the future.
Here you can get further information.