Influence of hormonal regulatory circuits on antitumor immune responses following radiation therapy

Project start
Institution: Department of Radiation Oncology, Technical University of Munich (TUM)
Applicant: Dr. Julius C. Fischer
EKFS funding line: Else Kröner Memorial Fellowships

The junior research group is investigating mechanisms to improve therapeutic response rates following radiation therapy or combined radioimmunotherapy. At the same time, the team is researching the underlying mechanisms of the side effects of such combination therapies. In this experimental research project the scientists want to investigate the influence of hormonal mechanisms on the development of antitumor immune responses following radiation therapy, or the combination of radiation therapy with immune checkpoint blockade. The project is based on the hypothesis that radiation therapy activates specific hormonal circuits that influence such antitumor immune responses. This knowledge could be used in the future to optimize cancer therapies.

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