Immunological processes play pivotal role in a variety of neurological diseases, including neoplastic conditions. Gliomas are highly malignant brain tumors which actively suppress anti-tumor immune responses. Current clinical imaging is mainly restricted to assess morphological information (e.g. tumor size, extent of edema and gliosis) but does not provide “functional” information on immune cell influx, cellular distributions and perturbations that occur after therapy induction. This, however, would be crucial to better understand and eventually treat neurological disorders including brain tumors. Furthermore, novel therapies that modulate the tumor microenvironment are entering clinical practice and require advanced treatment monitoring. The project aims to develop advanced imaging biomarkers of inflammatory processes.

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