Lynch syndrome is one of the most common inherited cancer syndromes. Affected individuals have a high cancer risk and require intensive cancer surveillance. Early identification of Lynch syndrome individuals is essential to enable their participation at surveillance programs and to prevent cancer. However, current methods to detect Lynch syndrome are limited; for example, diagnostic approaches normally require the presence of manifest tumors. Our group has identified immune responses against recurrent tumor-specific antigens in the blood of Lynch syndrome individuals. In this project we aim to evaluate whether immunological analyses could help identifying individuals affected by Lynch syndrome. If successful, such approaches could improve Lynch syndrome diagnostics in the future. 

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