Antibiotics focusing on novel cellular targets will help to fight multidrug-resistant, Gram-negative pathogens such as Klebsiella pneumoniae and Pseudomonas aeruginosa, and thus help to overcome the current AMR crisis. Enzymes of the bacterial energy metabolism have not been targeted so far. Based on our knowledge of the atomic, three-dimensional structure of the Na+ pump NQR, we will identify pharmacologically active compounds that inactivate this enzyme complex in pathogens and thus lead to their death. Due to the highly conserved structure of the enzyme throughout many Gram-negative pathogens, we expect that the compounds identified may serve as a starting point for the development of a whole new class of antibiotics.


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