Identification and functional validation of the proteome changes influencing the decline of the intestinal epithelium in aging

Project start
Institution: Leibniz Institute on Aging – Fritz Lipmann Institute (FLI)
Applicant: Alessandro Ori
EKFS funding line: First and Second Applications
Alessandro Ori, PhD

Stress resilience belongs to the most important characteristics of a multicellular organism and its organs. Unfortunately, with progressive age, or as a consequence of certain pathologies, this trait becomes weaker, thus making an organ like the small intestine more vulnerable towards external insults. Work from the Ori lab is going to address how dietary restriction is influencing the age-associated resilience decline of the small intestine. The results will support our understanding of aging-associated functional decline of the small intestine and hopefully direct further development of health supporting strategies.

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