Immune System

Harnessing tissue-specific chemokines for the recruitment of Natural Killer cells to liver cancer

Institution: Department of Medicine II, Klinikum rechts der Isar, Technical University of Munich
Applicant: PD Dr. Gabriela Wiedemann
Funding line:
First and Second Applications

Project description in easily understandable terms for the general public (800 characters incl. blanks):
Natural killer cells (NK cells) are central effector cells of the anti-tumor immune response. However, NK cell-based tumor therapies have shown promising results mostly in hematologic cancers, whereas the therapeutic usability of NK cells in solid tumors is often hampered by a poor NK cell infiltration into the tumor. Therefore, strategies aimed at improving NK cell migration into tumors are a key step to the advancement of NK cell-based therapies. In this project, we aim to investigate the role of chemokines for NK cell migration to the liver under physiologic and pathologic circumstances. The findings of this project will provide a crucial resource for the development of targeted NK cell-based therapies for liver cancer.

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