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Genetische Modulation von Redox-Signalwegen im Mausmodell der hypertrophen Kardiomyopathie

Institution: German Heart Center Munich, Department of congenital heart disease and pediatric cardiology, Technical University Munich
Applicant: Cordula M. Wolf, MD, Assistant Professor
Funding line:
First and Second Applications
Redox-signaling in hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is the most common inherited disorder characterized by progressive myocardial hypertrophy and fibrosis, and a high risk for arrhythmias. The disease is caused by mutations in genes encoding for proteins of the sarcomere.

There is no causative treatment available and the aim of current therapies is to prevent sudden cardiac death and pathologic myocardial remodeling.
Additional to the underlying genetic predisposition, there are multiple factors influencing disease course in HCM.

The objective of the current research project is to investigate the role of redox-signaling in a genetically engineered HCM-mouse model. The results of the study should provide more insight into HCM pathogenesis and help to initiate new treatment strategies.

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