Function and interaction between the blood-brain barrier and neuronal excitability as therapeutic strategies in the case of cerebral ischemia and central autoimmunity

Institution: Department of Neurology, University Medical Center, Johannes Gutenberg University Mainz
Applicant: Jun.-Prof. Dr. Timo Uphaus
Funding line:
Else Kröner Clinician Scientist Professorships
Jun.-Prof. Dr. Timo Uphaus

The demise of neuronal cells causes disabilities in the case of multiple sclerosis (MS) and a stroke. Jun.-Prof. Dr. Timo Uphaus researches the molecular causes of neuronal cell death in the course of these diseases. The focus thereby lies on the blood-brain barrier and its significance for the functioning of neural connections along with the influence of neuronal excitability on their survival. From the knowledge gained from these findings, “neuroprotective” therapy approaches are developed whose effectiveness will be tested in randomized clinical studies. The aim is to evolve  innovative therapeutic strategies for treating MS and strokes, and to enable their application in clinical practice.

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