Brain
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Effects of oxytocin receptor antagonization in migraine: A randomized, double-blind, placebo-controlled human provocation study

Institution: Charité Universitätsmedizin Berlin
Applicant: Dr. Bianca Raffaelli
Funding line:
First and Second Applications
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Migraine is a widespread and disabling headache disorder that affects women three times more often than men. Hormonal changes might trigger migraine attacks but the exact processes are not well understood.
This project focuses on oxytocin, a hormone known for relieving pain. We will investigate if blocking the effects of oxytocin can trigger migraine attacks in women with migraine. We will also explore the involved mechanisms, looking at changes in blood vessels and specific migraine markers. Men with migraine and healthy women without migraine will serve as comparison groups. The study aims to deepen our understanding of hormone-dependent aspects of migraine, potentially leading to innovative therapeutic approaches related to the oxytocin pathway.
 

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